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Assay Detail

CHEMBL806578

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of p185 erbB-2 oncoprotein in human breast cancer SK-BR-3 cells
ChEMBL ↗
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-BR-3
Confidence 1 — Organism
Curated By Expert

Target

SK-BR-3 (CHEMBL613834) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships.
Schnur RC, Corman ML, Gallaschun RJ, Cooper BA, Dee MF, Doty JL, Muzzi ML, DiOrio CI, Barbacci EG, Miller PE.
J Med Chem (1995) 38 : 3813 -3820
PubMed 7562912 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 53 6.59 7.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL339975 — — 1 7.85
CHEMBL433670 — — 1 7.64
CHEMBL109480 TANESPIMYCIN 3.0 1 7.51
CHEMBL341342 — — 1 7.47
CHEMBL125045 — — 1 7.47
CHEMBL339231 — — 1 7.43
CHEMBL340038 — — 1 7.43
CHEMBL339891 — — 1 7.40
CHEMBL435606 — — 1 7.30
CHEMBL123564 — — 1 7.29
CHEMBL331273 — — 1 7.22
CHEMBL278315 GELDANAMYCIN 2.0 1 7.16
CHEMBL443547 — — 1 7.16
CHEMBL341345 — — 1 7.16
CHEMBL124510 — — 1 7.10
CHEMBL334128 — — 1 7.05
CHEMBL333934 — — 1 7.05
CHEMBL127769 — — 1 6.85
CHEMBL124327 — — 1 6.85
CHEMBL339533 — — 1 6.85
CHEMBL338305 — — 1 6.77
CHEMBL124387 — — 1 6.72
CHEMBL127608 — — 1 6.70
CHEMBL126989 — — 1 6.70
CHEMBL125088 — — 1 6.66
CHEMBL340169 — — 1 6.64
CHEMBL406612 — — 1 6.64
CHEMBL340748 — — 1 6.58
CHEMBL435007 — — 1 6.57
CHEMBL127189 — — 1 6.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL339975 — IC50 = 14.0 nM 7.85
CHEMBL433670 — IC50 = 23.0 nM 7.64
CHEMBL109480 TANESPIMYCIN IC50 = 31.0 nM 7.51
CHEMBL341342 — IC50 = 34.0 nM 7.47
CHEMBL125045 — IC50 = 34.0 nM 7.47
CHEMBL339231 — IC50 = 37.0 nM 7.43
CHEMBL340038 — IC50 = 37.0 nM 7.43
CHEMBL339891 — IC50 = 40.0 nM 7.40
CHEMBL435606 — IC50 = 50.0 nM 7.30
CHEMBL123564 — IC50 = 51.0 nM 7.29
CHEMBL331273 — IC50 = 60.0 nM 7.22
CHEMBL278315 GELDANAMYCIN IC50 = 70.0 nM 7.16
CHEMBL443547 — IC50 = 70.0 nM 7.16
CHEMBL341345 — IC50 = 70.0 nM 7.16
CHEMBL124510 — IC50 = 80.0 nM 7.10
CHEMBL334128 — IC50 = 90.0 nM 7.05
CHEMBL333934 — IC50 = 90.0 nM 7.05
CHEMBL127769 — IC50 = 140.0 nM 6.85
CHEMBL124327 — IC50 = 140.0 nM 6.85
CHEMBL339533 — IC50 = 140.0 nM 6.85
CHEMBL338305 — IC50 = 170.0 nM 6.77
CHEMBL124387 — IC50 = 190.0 nM 6.72
CHEMBL127608 — IC50 = 200.0 nM 6.70
CHEMBL126989 — IC50 = 200.0 nM 6.70
CHEMBL125088 — IC50 = 220.0 nM 6.66
CHEMBL340169 — IC50 = 230.0 nM 6.64
CHEMBL406612 — IC50 = 230.0 nM 6.64
CHEMBL340748 — IC50 = 260.0 nM 6.58
CHEMBL435007 — IC50 = 270.0 nM 6.57
CHEMBL127189 — IC50 = 300.0 nM 6.52
CHEMBL338685 — IC50 = 300.0 nM 6.52
CHEMBL331914 — IC50 = 500.0 nM 6.30
CHEMBL435005 — IC50 = 600.0 nM 6.22
CHEMBL338831 — IC50 = 800.0 nM 6.10
CHEMBL340456 — IC50 = 830.0 nM 6.08
CHEMBL419613 — IC50 = 850.0 nM 6.07
CHEMBL127372 — IC50 = 1000.0 nM 6.00
CHEMBL444070 — IC50 = 1000.0 nM 6.00
CHEMBL340000 — IC50 = 1070.0 nM 5.97
CHEMBL436386 — IC50 = 1100.0 nM 5.96
CHEMBL339025 — IC50 = 1200.0 nM 5.92
CHEMBL340549 — IC50 = 1200.0 nM 5.92
CHEMBL127765 — IC50 = 1290.0 nM 5.89
CHEMBL333723 — IC50 = 1700.0 nM 5.77
CHEMBL341122 — IC50 = 1900.0 nM 5.72
CHEMBL433669 — IC50 = 2600.0 nM 5.58
CHEMBL126696 — IC50 = 3200.0 nM 5.50
CHEMBL126401 — IC50 = 3300.0 nM 5.48
CHEMBL436390 — IC50 = 3300.0 nM 5.48
CHEMBL420522 — IC50 = 3700.0 nM 5.43