Assay Detail
Binding
CHEMBL806640
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Inhibitory activity against mouse renin
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogues of angiotensinogen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.81 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL97865 | — | — | 1 | 6.40 |
| CHEMBL101874 | — | — | 1 | 6.30 |
| CHEMBL318242 | — | — | 1 | 6.00 |
| CHEMBL98582 | — | — | 1 | 5.50 |
| CHEMBL433013 | — | — | 1 | 5.44 |
| CHEMBL321937 | — | — | 1 | 5.19 |
| CHEMBL445118 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL97865 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL101874 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL318242 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL98582 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL433013 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL321937 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL445118 | — | IC50 | > | 100000.0 | nM | - |