Assay Detail
Binding
CHEMBL806876
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Inhibitory activity against Herpes simplex virus (HSV) ribonucleotide reductase (RR)
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Ribonucleoside-diphosphate reductase large subunit (CHEMBL3840) ↗| Type | SINGLE PROTEIN |
| Organism | Herpes simplex virus (type 1 / strain 17) |
Publication
Ureido-based peptidomimetic inhibitor of herpes simplex virus ribonucleotide reductase: an investigation of inhibitor bioactive conformation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.62 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305199 | — | — | 1 | 8.52 |
| CHEMBL70278 | — | — | 1 | 8.30 |
| CHEMBL37210 | — | — | 1 | 8.15 |
| CHEMBL420185 | — | — | 1 | 8.00 |
| CHEMBL71945 | — | — | 1 | 7.82 |
| CHEMBL305229 | — | — | 1 | 7.62 |
| CHEMBL70879 | — | — | 2 | 7.50 |
| CHEMBL2369478 | — | — | 1 | 7.46 |
| CHEMBL2369482 | — | — | 1 | 6.97 |
| CHEMBL267068 | — | — | 1 | 6.85 |
| CHEMBL305482 | — | — | 1 | 6.62 |
| CHEMBL71721 | — | — | 1 | 6.36 |
| CHEMBL262933 | — | — | 1 | 6.20 |
| CHEMBL305067 | — | — | 1 | 6.17 |
| CHEMBL68987 | — | — | 1 | 6.10 |
| CHEMBL445620 | — | — | 1 | 6.07 |
| CHEMBL306879 | — | — | 1 | 6.06 |
| CHEMBL2369479 | — | — | 1 | 4.39 |
| CHEMBL303618 | — | — | 1 | 4.38 |
| CHEMBL2369480 | — | — | 1 | 4.00 |
| CHEMBL2369481 | — | — | 1 | - |
| CHEMBL68193 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305199 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL70278 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL37210 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL420185 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL71945 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL305229 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL70879 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2369478 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2369482 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL267068 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL305482 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL71721 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL262933 | — | IC50 | = | 635.0 | nM | 6.20 |
| CHEMBL305067 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL68987 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL445620 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL306879 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL70879 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2369479 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL303618 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL2369480 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2369481 | — | IC50 | = | 750000.0 | nM | - |
| CHEMBL68193 | — | IC50 | = | 110000.0 | nM | - |