Assay Detail
Binding
CHEMBL806888
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Concentration required to reduce Ribonucleotide reductase rate by 50% in L1210 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dinucleotide analogues as inhibitors of thymidine kinase, thymidylate kinase, and ribonucleotide reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.55 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1236157 | — | — | 1 | 4.85 |
| CHEMBL604405 | — | — | 1 | 4.70 |
| CHEMBL1794614 | — | — | 1 | 4.11 |
| CHEMBL605228 | — | — | 1 | - |
| CHEMBL604419 | — | — | 1 | - |
| CHEMBL606301 | — | — | 1 | - |
| CHEMBL605435 | — | — | 1 | - |
| CHEMBL604420 | — | — | 1 | - |
| CHEMBL606084 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1236157 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL604405 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1794614 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL605228 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL604419 | — | IC50 | = | 460000.0 | nM | - |
| CHEMBL606301 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL605435 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL604420 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL606084 | — | IC50 | = | 230000.0 | nM | - |