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Assay Detail

CHEMBL807105

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards human Somatostatin receptor type 3 using 125I-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand
16
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Somatostatin receptor type 3 (CHEMBL2028)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel sst(4)-selective somatostatin (SRIF) agonists. 4. Three-dimensional consensus structure by NMR.
Grace CR, Koerber SC, Erchegyi J, Reubi JC, Rivier J, Riek R.
J Med Chem (2003) 46 : 5606 -5618
PubMed 14667215 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.79 7.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1824055 1 7.89
CHEMBL452157 1 7.89
CHEMBL2371100 1 7.85
CHEMBL3350357 1 7.75
CHEMBL2371070 1 6.39
CHEMBL3350907 1 6.35
CHEMBL2371108 1 6.18
CHEMBL3350902 1 6.14
CHEMBL3350888 1 6.12
CHEMBL2111200 1 6.08
CHEMBL3350896 1 6.05
CHEMBL3350913 2 -
CHEMBL3350901 1 -
CHEMBL3350906 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1824055 IC50 = 13.0 nM 7.89
CHEMBL452157 IC50 = 13.0 nM 7.89
CHEMBL2371100 IC50 = 14.0 nM 7.85
CHEMBL3350357 IC50 = 18.0 nM 7.75
CHEMBL2371070 IC50 = 403.0 nM 6.39
CHEMBL3350907 IC50 = 447.0 nM 6.35
CHEMBL2371108 IC50 = 664.0 nM 6.18
CHEMBL3350902 IC50 = 725.0 nM 6.14
CHEMBL3350888 IC50 = 750.0 nM 6.12
CHEMBL2111200 IC50 = 825.0 nM 6.08
CHEMBL3350896 IC50 = 897.0 nM 6.05
CHEMBL3350913 IC50 > 1000.0 nM -
CHEMBL3350913 IC50 > 10000.0 nM -
CHEMBL3350901 IC50 > 1000.0 nM -
CHEMBL3350906 IC50 > 10000.0 nM -
CHEMBL3350906 IC50 > 1000.0 nM -