Assay Detail
Functional
CHEMBL807120
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of DHT (dihydrotestosterone) on proliferation of androgen-sensitive cancer Schionogi (SC-3) cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and in vitro activity of 17 beta-(N-alkyl/arylformamido)- and 17 beta-[(N-alkyl/aryl)alkyl/arylamido]-4-methyl-4-aza-3-oxo-5 alpha-androstan-3-ones as inhibitors of human 5 alpha-reductases and antagonists of the androgen receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.78 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17222 | — | — | 1 | 7.34 |
| CHEMBL417627 | — | — | 1 | 7.30 |
| CHEMBL491 | HYDROXYFLUTAMIDE | 2.0 | 1 | 7.28 |
| CHEMBL17206 | — | — | 1 | 7.24 |
| CHEMBL17506 | — | — | 1 | 7.05 |
| CHEMBL16533 | — | — | 1 | 7.05 |
| CHEMBL275153 | — | — | 1 | 7.02 |
| CHEMBL16927 | — | — | 1 | 6.96 |
| CHEMBL17268 | — | — | 1 | 6.79 |
| CHEMBL277053 | — | — | 1 | 6.78 |
| CHEMBL16863 | — | — | 1 | 6.77 |
| CHEMBL2298601 | — | — | 1 | 6.33 |
| CHEMBL16690 | — | — | 1 | 6.00 |
| CHEMBL274276 | — | — | 1 | 6.00 |
| CHEMBL17193 | — | — | 1 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17222 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL417627 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL491 | HYDROXYFLUTAMIDE | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL17206 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL17506 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL16533 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL275153 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL16927 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL17268 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL277053 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL16863 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL2298601 | — | IC50 | = | 463.0 | nM | 6.33 |
| CHEMBL16690 | — | IC50 | = | 994.0 | nM | 6.00 |
| CHEMBL274276 | — | IC50 | = | 989.0 | nM | 6.00 |
| CHEMBL17193 | — | IC50 | = | 1476.0 | nM | 5.83 |