Assay Detail
Functional
CHEMBL807246
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonism of in vitro SRIF inhibition of GH release in rat in vitro pituitary cell assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | Pituitary gland cell |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Highly potent cyclic disulfide antagonists of somatostatin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 7.42 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2311098 | — | — | 1 | 8.96 |
| CHEMBL439005 | — | — | 1 | 8.85 |
| CHEMBL2372961 | — | — | 1 | 8.74 |
| CHEMBL2372963 | — | — | 1 | 8.60 |
| CHEMBL408347 | — | — | 1 | 8.59 |
| CHEMBL437220 | — | — | 1 | 8.59 |
| CHEMBL385746 | — | — | 1 | 8.57 |
| CHEMBL437448 | — | — | 1 | 8.57 |
| CHEMBL439136 | — | — | 1 | 8.52 |
| CHEMBL264028 | — | — | 1 | 8.40 |
| CHEMBL2372957 | — | — | 1 | 8.23 |
| CHEMBL415201 | — | — | 1 | 8.19 |
| CHEMBL2372960 | — | — | 1 | 8.08 |
| CHEMBL275806 | — | — | 1 | 7.92 |
| CHEMBL414386 | — | — | 1 | 7.82 |
| CHEMBL413709 | — | — | 1 | 7.70 |
| CHEMBL2372964 | — | — | 1 | 7.70 |
| CHEMBL2372962 | — | — | 1 | 7.50 |
| CHEMBL406738 | — | — | 1 | 7.42 |
| CHEMBL410181 | — | — | 1 | 7.32 |
| CHEMBL384607 | — | — | 1 | 7.29 |
| CHEMBL408787 | — | — | 1 | 7.19 |
| CHEMBL2372956 | — | — | 1 | 7.15 |
| CHEMBL412561 | — | — | 1 | 7.13 |
| CHEMBL406152 | — | — | 1 | 7.11 |
| CHEMBL2372959 | — | — | 1 | 7.09 |
| CHEMBL407195 | — | — | 1 | 7.06 |
| CHEMBL412859 | — | — | 1 | 7.04 |
| CHEMBL407496 | — | — | 1 | 6.98 |
| CHEMBL438281 | — | — | 1 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2311098 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL439005 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2372961 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL2372963 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL408347 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL437220 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL385746 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL437448 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL439136 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL264028 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2372957 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL415201 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL2372960 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL275806 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL414386 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL413709 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2372964 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2372962 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL406738 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL410181 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL384607 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL408787 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2372956 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL412561 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL406152 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL2372959 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL407195 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL412859 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL407496 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL438281 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL429166 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL385745 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL411556 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL385689 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL413171 | — | IC50 | = | 292.0 | nM | 6.54 |
| CHEMBL406491 | — | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL2372958 | — | IC50 | = | 403.0 | nM | 6.39 |
| CHEMBL414116 | — | IC50 | = | 425.0 | nM | 6.37 |
| CHEMBL437057 | — | IC50 | = | 765.0 | nM | 6.12 |
| CHEMBL408987 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL264539 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL414598 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL439350 | — | IC50 | - | nM | - | |
| CHEMBL438726 | — | IC50 | - | nM | - |