Assay Detail
Binding
CHEMBL807594
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Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.02 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119116 | — | — | 1 | 8.18 |
| CHEMBL119440 | — | — | 1 | 7.82 |
| CHEMBL441826 | — | — | 1 | 7.75 |
| CHEMBL332667 | — | — | 1 | 7.64 |
| CHEMBL119256 | — | — | 1 | 7.58 |
| CHEMBL331054 | — | — | 1 | 7.50 |
| CHEMBL118783 | — | — | 1 | 7.48 |
| CHEMBL119354 | — | — | 1 | 7.44 |
| CHEMBL118860 | — | — | 1 | 7.40 |
| CHEMBL118815 | — | — | 1 | 7.38 |
| CHEMBL119413 | — | — | 1 | 7.26 |
| CHEMBL117715 | — | — | 1 | 7.24 |
| CHEMBL119873 | — | — | 1 | 7.23 |
| CHEMBL333335 | — | — | 1 | 7.13 |
| CHEMBL117723 | — | — | 1 | 7.10 |
| CHEMBL432813 | — | — | 1 | 7.05 |
| CHEMBL323617 | — | — | 1 | 6.92 |
| CHEMBL116981 | — | — | 1 | 6.92 |
| CHEMBL115970 | — | — | 1 | 6.60 |
| CHEMBL325247 | — | — | 1 | 6.58 |
| CHEMBL119382 | — | — | 1 | 6.57 |
| CHEMBL324820 | — | — | 1 | 6.38 |
| CHEMBL118508 | — | — | 1 | 6.35 |
| CHEMBL332373 | — | — | 1 | 6.28 |
| CHEMBL117403 | — | — | 1 | 6.16 |
| CHEMBL119239 | — | — | 1 | 5.92 |
| CHEMBL117007 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119116 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL119440 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL441826 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL332667 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL119256 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL331054 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL118783 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL119354 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL118860 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL118815 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL119413 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL117715 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL119873 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL333335 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL117723 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL432813 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL323617 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL116981 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL115970 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL325247 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL119382 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL324820 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL118508 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL332373 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL117403 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL119239 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL117007 | — | IC50 | = | 2100.0 | nM | 5.68 |