Assay Detail
Binding
CHEMBL807672
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Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of new potent, silent 5-HT1A antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.43 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113752 | — | — | 1 | 8.23 |
| CHEMBL444794 | — | — | 1 | 8.17 |
| CHEMBL116809 | — | — | 1 | 8.11 |
| CHEMBL326088 | — | — | 1 | 7.80 |
| CHEMBL115003 | — | — | 1 | 7.73 |
| CHEMBL116626 | — | — | 1 | 7.48 |
| CHEMBL114893 | — | — | 1 | 7.44 |
| CHEMBL117972 | — | — | 1 | 7.34 |
| CHEMBL113960 | — | — | 1 | 7.22 |
| CHEMBL117405 | — | — | 1 | 6.96 |
| CHEMBL117269 | — | — | 1 | 6.85 |
| CHEMBL116444 | — | — | 1 | 6.81 |
| CHEMBL117825 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113752 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL444794 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL116809 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL326088 | — | Ki | = | 15.7 | nM | 7.80 |
| CHEMBL115003 | — | Ki | = | 18.7 | nM | 7.73 |
| CHEMBL116626 | — | Ki | = | 32.9 | nM | 7.48 |
| CHEMBL114893 | — | Ki | = | 36.4 | nM | 7.44 |
| CHEMBL117972 | — | Ki | = | 45.4 | nM | 7.34 |
| CHEMBL113960 | — | Ki | = | 60.3 | nM | 7.22 |
| CHEMBL117405 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL117269 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL116444 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL117825 | — | Ki | = | 391.0 | nM | 6.41 |