Assay Detail
Binding
CHEMBL807702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was evaluated in vitro for the inhibition of rat leukocyte elastase(RLE)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Chymotrypsin-like elastase family member 2A (CHEMBL3888) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Enantioselective synthesis and antielastase activity of 1,3,4-trisubstituted and 3,4-disubstituted -lactam antibiotics
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.65 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84758 | — | — | 1 | 6.40 |
| CHEMBL431207 | — | — | 1 | 6.30 |
| CHEMBL24983 | — | — | 1 | 6.16 |
| CHEMBL310133 | — | — | 1 | 4.96 |
| CHEMBL418925 | — | — | 1 | 4.43 |
| CHEMBL85693 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84758 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL431207 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL24983 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL310133 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL418925 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL85693 | — | IC50 | > | 160000.0 | nM | - |