Assay Detail
Binding
CHEMBL807722
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for Retinoic acid receptor beta
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of 1,2,3,4-tetrahydroquinoline and 3,4-(1H)-dihydroquinolin-2-one analogs of retinoic acid
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 7.37 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275311 | — | — | 1 | 8.30 |
| CHEMBL76313 | — | — | 1 | 7.77 |
| CHEMBL430616 | — | — | 1 | 7.75 |
| CHEMBL80271 | — | — | 1 | 7.75 |
| CHEMBL311269 | — | — | 1 | 7.22 |
| CHEMBL75741 | — | — | 1 | 6.68 |
| CHEMBL80820 | — | — | 1 | 6.15 |
| CHEMBL308967 | — | — | 1 | - |
| CHEMBL306999 | — | — | 1 | - |
| CHEMBL80934 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275311 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL76313 | — | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL430616 | — | Kd | = | 18.0 | nM | 7.75 |
| CHEMBL80271 | — | Kd | = | 18.0 | nM | 7.75 |
| CHEMBL311269 | — | Kd | = | 60.0 | nM | 7.22 |
| CHEMBL75741 | — | Kd | = | 211.0 | nM | 6.68 |
| CHEMBL80820 | — | Kd | = | 714.0 | nM | 6.15 |
| CHEMBL308967 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL306999 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL80934 | — | Kd | > | 1000.0 | nM | - |