Assay Detail
Functional
CHEMBL807825
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-induced tumor necrosis factor-alpha (TNF-alpha) production in THP-1 cells
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 6.16 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 7.75 |
| CHEMBL10 | SB-203580 | — | 1 | 7.22 |
| CHEMBL314228 | — | — | 1 | 6.92 |
| CHEMBL85461 | — | — | 1 | 6.89 |
| CHEMBL315100 | — | — | 1 | 6.75 |
| CHEMBL312873 | — | — | 1 | 6.60 |
| CHEMBL100847 | — | — | 1 | 6.48 |
| CHEMBL420047 | — | — | 1 | 6.43 |
| CHEMBL84777 | — | — | 1 | 6.42 |
| CHEMBL86318 | — | — | 1 | 6.39 |
| CHEMBL314805 | — | — | 1 | 6.20 |
| CHEMBL102547 | — | — | 1 | 6.16 |
| CHEMBL314023 | — | — | 1 | 6.14 |
| CHEMBL420231 | — | — | 1 | 6.11 |
| CHEMBL314278 | — | — | 1 | 6.09 |
| CHEMBL87224 | — | — | 1 | 6.02 |
| CHEMBL86195 | — | — | 1 | 6.00 |
| CHEMBL85860 | — | — | 1 | 6.00 |
| CHEMBL84928 | — | — | 1 | 5.92 |
| CHEMBL87580 | — | — | 1 | 5.89 |
| CHEMBL312895 | — | — | 1 | 5.80 |
| CHEMBL315059 | — | — | 1 | 5.72 |
| CHEMBL85609 | — | — | 1 | 5.64 |
| CHEMBL85942 | — | — | 1 | 5.48 |
| CHEMBL87277 | — | — | 1 | 5.23 |
| CHEMBL101035 | — | — | 1 | 5.21 |
| CHEMBL407173 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103667 | DORAMAPIMOD | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL10 | SB-203580 | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL314228 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL85461 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL315100 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL312873 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL100847 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL420047 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL84777 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL86318 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL314805 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL102547 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL314023 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL420231 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL314278 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL87224 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL86195 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL85860 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL84928 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL87580 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL312895 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL315059 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL85609 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL85942 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL87277 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL101035 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL407173 | — | EC50 | = | 11000.0 | nM | 4.96 |