Assay Detail
Binding
CHEMBL807898
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SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Solution structures in SDS micelles and functional activity at the bullfrog substance P receptor of ranatachykinin peptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.54 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235363 | SUBSTANCE P | 1.0 | 1 | 9.22 |
| CHEMBL384518 | — | — | 1 | 9.22 |
| CHEMBL263185 | — | — | 1 | 7.85 |
| CHEMBL415159 | TYRLYSSERASPSERPHETYRGLYLEUMET | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235363 | SUBSTANCE P | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL384518 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL263185 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL415159 | TYRLYSSERASPSERPHETYRGLYLEUMET | EC50 | = | 14.0 | nM | 7.85 |