Compound Detail
CHEMBL415159
TYRLYSSERASPSERPHETYRGLYLEUMET Enter ChEMBL ID:
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CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O
Basic Information
| ChEMBL ID | CHEMBL415159 |
| Name | TYRLYSSERASPSERPHETYRGLYLEUMET |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | ONJQALZQTBFYIT-NVAZTIMOSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1209.4
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Substance-P receptor CHEMBL249 | EC50 | 7.85 | 7.85 | 14.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Substance-P receptor | EC50 | = | 14.0 | nM | 7.85 | Agonist activity at bfSPR to produce increase in intracellular [Ca2+] | 10794691 |
| Substance-P receptor | EC50 | = | 14.0 | nM | 7.85 | SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor... | 10794691 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10794691 | 10.1021/jm000093v | Substance-P receptor | 3 |
Data from ChEMBL 36 via Core Engine