Assay Detail
Functional
CHEMBL807977
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Cell free inhibiting activity against erythromycin-susceptible strain Streptococcus pneumoniae 5635 (Wild type ribosomes for transcription/translation assay)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Streptococcus pneumoniae |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.84 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL335552 | — | — | 1 | 7.16 |
| CHEMBL532 | ERYTHROMYCIN | 4.0 | 1 | 6.92 |
| CHEMBL335696 | — | — | 1 | 6.82 |
| CHEMBL132146 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL335552 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL532 | ERYTHROMYCIN | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL335696 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL132146 | — | IC50 | = | 350.0 | nM | 6.46 |