Assay Detail
Functional
CHEMBL807979
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Inhibitory concentration against purified cephalosporin-resistant PBP2x.505 from Streptococcus pneumoniae
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Streptococcus pneumoniae |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.11 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53624 | RO 25-6833 | — | 1 | 6.44 |
| CHEMBL148 | IMIPENEM ANHYDROUS | 4.0 | 1 | 6.30 |
| CHEMBL161 | CEFTRIAXONE | 4.0 | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53624 | RO 25-6833 | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL148 | IMIPENEM ANHYDROUS | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL161 | CEFTRIAXONE | IC50 | = | 2500.0 | nM | 5.60 |