Assay Detail
Binding
CHEMBL808215
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Inhibitory activity against HepG2 Squalene Synthase (SQS)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of J-104,118, a novel, potent inhibitor of squalene synthase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.39 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40991 | ZARAGOZIC ACID A | — | 1 | 9.62 |
| CHEMBL61985 | — | — | 1 | 9.28 |
| CHEMBL2115091 | — | — | 1 | 9.14 |
| CHEMBL61935 | — | — | 1 | 8.92 |
| CHEMBL59729 | — | — | 1 | 8.49 |
| CHEMBL292530 | — | — | 1 | 7.80 |
| CHEMBL59440 | — | — | 1 | 7.72 |
| CHEMBL59981 | — | — | 1 | 6.18 |
| CHEMBL60151 | — | — | 1 | - |
| CHEMBL303794 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40991 | ZARAGOZIC ACID A | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL61985 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL2115091 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL61935 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL59729 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL292530 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL59440 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL59981 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL60151 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL303794 | — | IC50 | > | 300.0 | nM | - |