Assay Detail
Functional
CHEMBL808299
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Compound was evaluated for in vitro activity against SK-MEL-5 Melanoma cell lines (Human tumor cells )
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl- L-ornithine (PT523).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.19 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150607 | — | — | 1 | 9.19 |
| CHEMBL18155 | — | — | 1 | 8.33 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150607 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL18155 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 87.0 | nM | 7.06 |