Assay Detail
Binding
CHEMBL808335
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Inhibitory activity against Thrombin
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.29 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308948 | — | — | 1 | 6.96 |
| CHEMBL75084 | — | — | 1 | 6.82 |
| CHEMBL77490 | — | — | 1 | 5.10 |
| CHEMBL77076 | — | — | 1 | - |
| CHEMBL77982 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308948 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL75084 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL77490 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL77076 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL77982 | — | IC50 | < | 40.0 | nM | - |