Assay Detail
Binding
CHEMBL808365
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit human trk A tyrosine kinase expressed in baculovirus using ELISA based enzyme assay was determined
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
High affinity nerve growth factor receptor (CHEMBL2815) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.29 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281948 | K-252A | — | 1 | 8.62 |
| CHEMBL53885 | — | — | 1 | 6.68 |
| CHEMBL291985 | — | — | 1 | 6.57 |
| CHEMBL444039 | — | — | 1 | - |
| CHEMBL55567 | — | — | 1 | - |
| CHEMBL301144 | — | — | 1 | - |
| CHEMBL433281 | — | — | 1 | - |
| CHEMBL299496 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281948 | K-252A | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL53885 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL291985 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL444039 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL55567 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL301144 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL433281 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL299496 | — | IC50 | > | 1000.0 | nM | - |