Assay Detail
Binding
CHEMBL808517
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Binding Affinity of [125I]-MePhe7-NKB towards Tachykinin receptor 3-CHO cell membranes(n=3-8)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2-Phenyl-4-quinolinecarboxamides: a novel class of potent and selective non-peptide competitive antagonists for the human neurokinin-3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.92 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10188 | TALNETANT | 2.0 | 1 | 9.00 |
| CHEMBL346178 | OSANETANT | 2.0 | 1 | 8.92 |
| CHEMBL10284 | SB-222200 | — | 1 | 8.38 |
| CHEMBL9643 | — | — | 1 | 7.88 |
| CHEMBL9960 | AZD-7624 | 2.0 | 1 | 7.75 |
| CHEMBL429951 | — | — | 1 | 7.51 |
| CHEMBL9843 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10188 | TALNETANT | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL346178 | OSANETANT | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL10284 | SB-222200 | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL9643 | — | Ki | = | 13.3 | nM | 7.88 |
| CHEMBL9960 | AZD-7624 | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL429951 | — | Ki | = | 30.7 | nM | 7.51 |
| CHEMBL9843 | — | Ki | = | 925.0 | nM | 6.03 |