Assay Detail
Binding
CHEMBL808526
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In vitro inhibition of thromboxane synthase
12
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Thia-prostanoid analogs with combined thromboxane receptor antagonist/thromboxane synthase inhibitor activities. Synthesis and pharmacological evaluation
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.03 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65414 | — | — | 1 | 8.70 |
| CHEMBL48092 | PIRMAGREL | 2.0 | 1 | 8.52 |
| CHEMBL292331 | — | — | 3 | 8.00 |
| CHEMBL62834 | — | — | 1 | 7.96 |
| CHEMBL65161 | — | — | 1 | 7.37 |
| CHEMBL2115559 | — | — | 1 | - |
| CHEMBL292740 | — | — | 1 | - |
| CHEMBL63056 | — | — | 1 | - |
| CHEMBL62852 | — | — | 1 | - |
| CHEMBL2115518 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65414 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL48092 | PIRMAGREL | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL292331 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL62834 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL292331 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL292331 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL65161 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2115559 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL292740 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL63056 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL62852 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL2115518 | — | IC50 | > | 200.0 | nM | - |