Assay Detail
Binding
CHEMBL808527
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In vitro inhibition against thromboxane synthase
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Oxa-prostanoid analogs. Identification of an orally effective, dual thromboxane receptor antagonist /thromboxane synthase inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.83 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65414 | — | — | 1 | 8.70 |
| CHEMBL280728 | RIDOGREL | 2.0 | 1 | 8.52 |
| CHEMBL63040 | — | — | 3 | 8.37 |
| CHEMBL302457 | — | — | 1 | 7.66 |
| CHEMBL65622 | — | — | 1 | 7.50 |
| CHEMBL294353 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65414 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL280728 | RIDOGREL | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL63040 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL63040 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL302457 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL65622 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL294353 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL63040 | — | IC50 | = | 120.0 | nM | 6.92 |