Assay Detail
Binding
CHEMBL808529
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of thromboxane synthase (TSI) activity was determined by using human serum levels of TXB2
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Serum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 2. Design, synthesis, and evaluation of a novel series of phenyl oxazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.13 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293764 | — | — | 1 | 7.72 |
| CHEMBL57359 | — | — | 1 | 7.64 |
| CHEMBL57576 | — | — | 1 | 7.61 |
| CHEMBL60710 | — | — | 1 | 7.60 |
| CHEMBL291539 | — | — | 1 | 7.51 |
| CHEMBL61306 | — | — | 1 | 7.42 |
| CHEMBL26820 | (E)-ISBOGREL | — | 1 | 7.31 |
| CHEMBL299467 | — | — | 2 | 7.26 |
| CHEMBL56778 | — | — | 1 | 7.09 |
| CHEMBL58332 | — | — | 1 | 7.09 |
| CHEMBL56722 | — | — | 1 | 6.64 |
| CHEMBL418323 | — | — | 1 | 5.50 |
| CHEMBL59547 | — | — | 1 | - |
| CHEMBL60516 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293764 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL57359 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL57576 | — | IC50 | = | 24.7 | nM | 7.61 |
| CHEMBL60710 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL291539 | — | IC50 | = | 31.2 | nM | 7.51 |
| CHEMBL61306 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL26820 | (E)-ISBOGREL | IC50 | = | 48.7 | nM | 7.31 |
| CHEMBL299467 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL56778 | — | IC50 | = | 82.1 | nM | 7.09 |
| CHEMBL58332 | — | IC50 | = | 82.1 | nM | 7.09 |
| CHEMBL56722 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL299467 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL418323 | — | IC50 | = | 3167.0 | nM | 5.50 |
| CHEMBL59547 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL60516 | — | IC50 | > | 10000.0 | nM | - |