Assay Detail
Binding
CHEMBL808531
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In vitro inhibitory activity against human microsomal thromboxane synthase.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A novel approach to dual-acting thromboxane receptor antagonist/synthase inhibitors based on the link of 1,3-dioxane-thromboxane receptor antagonists and -thromboxane synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.34 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297385 | — | — | 1 | 8.00 |
| CHEMBL291167 | — | — | 1 | 8.00 |
| CHEMBL42677 | — | — | 1 | 8.00 |
| CHEMBL40425 | — | — | 1 | 7.70 |
| CHEMBL26820 | (E)-ISBOGREL | — | 1 | 7.70 |
| CHEMBL290483 | — | — | 1 | 7.52 |
| CHEMBL290882 | — | — | 1 | 7.52 |
| CHEMBL263516 | — | — | 1 | 7.52 |
| CHEMBL41945 | — | — | 1 | 7.52 |
| CHEMBL44422 | — | — | 1 | 7.52 |
| CHEMBL290281 | — | — | 1 | 7.52 |
| CHEMBL417163 | — | — | 1 | 7.40 |
| CHEMBL41904 | — | — | 1 | 7.40 |
| CHEMBL288194 | — | — | 1 | 7.40 |
| CHEMBL42738 | — | — | 1 | 7.40 |
| CHEMBL43468 | — | — | 1 | 7.40 |
| CHEMBL44865 | — | — | 1 | 7.40 |
| CHEMBL290205 | — | — | 1 | 7.30 |
| CHEMBL43488 | — | — | 1 | 7.30 |
| CHEMBL287720 | — | — | 1 | 7.30 |
| CHEMBL43756 | — | — | 1 | 7.22 |
| CHEMBL44094 | — | — | 1 | 7.22 |
| CHEMBL41989 | — | — | 1 | 7.16 |
| CHEMBL267473 | DAZOXIBEN | 2.0 | 1 | 7.16 |
| CHEMBL288118 | — | — | 1 | 5.77 |
| CHEMBL294952 | — | — | 1 | 5.42 |
| CHEMBL42263 | — | — | 1 | - |
| CHEMBL24984 | — | — | 1 | - |
| CHEMBL30024 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297385 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL291167 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL42677 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL40425 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL26820 | (E)-ISBOGREL | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL290483 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL290882 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL263516 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL41945 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL44422 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL290281 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL417163 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL41904 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL288194 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL42738 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL43468 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL44865 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL290205 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL43488 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL287720 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL43756 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL44094 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL41989 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL267473 | DAZOXIBEN | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL288118 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL294952 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL42263 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL24984 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL30024 | — | IC50 | > | 100000.0 | nM | - |