Assay Detail
Binding
CHEMBL808532
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Inhibition of human platelet thromboxane synthase (TXA2) was determined in human platelets
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N-(heterocyclic alkyl)pyrido[2,1-b]quinazoline-8-carboxamides as orally active antiallergy agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.69 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL60625 | — | — | 1 | 7.70 |
| CHEMBL57489 | — | — | 1 | 7.70 |
| CHEMBL56418 | — | — | 1 | 7.70 |
| CHEMBL1202758 | — | — | 1 | 7.30 |
| CHEMBL57480 | — | — | 1 | 7.22 |
| CHEMBL57716 | — | — | 1 | 7.22 |
| CHEMBL300338 | — | — | 1 | 7.00 |
| CHEMBL1204216 | — | — | 1 | 7.00 |
| CHEMBL1204214 | — | — | 1 | 7.00 |
| CHEMBL58518 | — | — | 1 | 7.00 |
| CHEMBL1204213 | — | — | 1 | 7.00 |
| CHEMBL1204224 | — | — | 1 | 7.00 |
| CHEMBL1204215 | — | — | 1 | 7.00 |
| CHEMBL60930 | — | — | 1 | 6.70 |
| CHEMBL294706 | — | — | 1 | 6.70 |
| CHEMBL293362 | — | — | 1 | 6.70 |
| CHEMBL1204223 | — | — | 1 | 6.70 |
| CHEMBL57736 | — | — | 1 | 6.70 |
| CHEMBL267473 | DAZOXIBEN | 2.0 | 1 | 6.60 |
| CHEMBL60572 | — | — | 1 | 6.52 |
| CHEMBL418452 | — | — | 1 | 6.52 |
| CHEMBL301215 | — | — | 1 | 6.30 |
| CHEMBL1202757 | — | — | 1 | 6.22 |
| CHEMBL1202763 | — | — | 1 | 6.22 |
| CHEMBL1202755 | — | — | 1 | 6.00 |
| CHEMBL1204218 | — | — | 1 | 5.40 |
| CHEMBL1202756 | — | — | 1 | 5.30 |
| CHEMBL267475 | FPL-55712 | — | 1 | 5.00 |
| CHEMBL56742 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL60625 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL57489 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL56418 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1202758 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL57480 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL57716 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL300338 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1204216 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1204214 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL58518 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1204213 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1204224 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1204215 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL60930 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL294706 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL293362 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1204223 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL57736 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL267473 | DAZOXIBEN | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL60572 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL418452 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL301215 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1202757 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1202763 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1202755 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1204218 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1202756 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL267475 | FPL-55712 | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL56742 | — | IC50 | > | 10000.0 | nM | - |