Assay Detail
Functional
CHEMBL808536
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of thromboxane synthase (TXA2) in human platelet microsomes [reduced formation of TXB2 from prostaglandin H2(PGH2)]
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Subcellular | Microsome |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel agents combining platelet activating factor (PAF) receptor antagonist with thromboxane synthase inhibitor (TxSI).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.35 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28196 | ISBOGREL | 2.0 | 1 | 9.05 |
| CHEMBL165575 | — | — | 1 | 9.00 |
| CHEMBL352120 | — | — | 1 | 7.68 |
| CHEMBL11662 | OZAGREL | 4.0 | 1 | 7.62 |
| CHEMBL164665 | — | — | 1 | 7.62 |
| CHEMBL165359 | — | — | 1 | 7.39 |
| CHEMBL349982 | — | — | 1 | 7.24 |
| CHEMBL350961 | — | — | 1 | 7.23 |
| CHEMBL323798 | — | — | 1 | 7.19 |
| CHEMBL423993 | — | — | 1 | 7.19 |
| CHEMBL354662 | — | — | 1 | 7.17 |
| CHEMBL166193 | — | — | 1 | 7.16 |
| CHEMBL408135 | — | — | 1 | 7.14 |
| CHEMBL349150 | — | — | 1 | 7.14 |
| CHEMBL164123 | — | — | 1 | 7.10 |
| CHEMBL164758 | — | — | 1 | 6.82 |
| CHEMBL351562 | — | — | 1 | 6.33 |
| CHEMBL351024 | — | — | 1 | 6.27 |
| CHEMBL166208 | — | — | 1 | - |
| CHEMBL351224 | — | — | 1 | - |
| CHEMBL424160 | — | — | 1 | - |
| CHEMBL29067 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28196 | ISBOGREL | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL165575 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL352120 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL11662 | OZAGREL | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL164665 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL165359 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL349982 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL350961 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL323798 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL423993 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL354662 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL166193 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL408135 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL349150 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL164123 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL164758 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL351562 | — | IC50 | = | 465.0 | nM | 6.33 |
| CHEMBL351024 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL166208 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL351224 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL424160 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL29067 | — | IC50 | - | nM | - |