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Assay Detail

CHEMBL808712

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibitory concentration against Trypanosoma cruzi intracellular amastigotes
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi.
Magaraci F, Jimenez CJ, Rodrigues C, Rodrigues JC, Braga MV, Yardley V, de Luca-Fradley K, Croft SL, de Souza W, Ruiz-Perez LM, Urbina J, Gonzalez Pacanowska D, Gilbert IH.
J Med Chem (2003) 46 : 4714 -4727
PubMed 14561091 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.58 5.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3138264 1 5.21
CHEMBL2069130 1 5.13
CHEMBL3137954 1 4.88
CHEMBL3138271 1 4.75
CHEMBL3137953 1 4.64
CHEMBL3138308 1 4.48
CHEMBL3138416 1 4.46
CHEMBL3138499 1 4.38
CHEMBL2069129 1 4.30
CHEMBL3138302 1 4.30
CHEMBL3138314 1 4.29
CHEMBL3137952 1 4.19
CHEMBL3137957 1 -
CHEMBL3138270 1 -
CHEMBL3138393 1 -
CHEMBL3137946 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3138264 IC50 = 6100.0 nM 5.21
CHEMBL2069130 IC50 = 7400.0 nM 5.13
CHEMBL3137954 IC50 = 13300.0 nM 4.88
CHEMBL3138271 IC50 = 18000.0 nM 4.75
CHEMBL3137953 IC50 = 22800.0 nM 4.64
CHEMBL3138308 IC50 = 32900.0 nM 4.48
CHEMBL3138416 IC50 = 35000.0 nM 4.46
CHEMBL3138499 IC50 = 42100.0 nM 4.38
CHEMBL2069129 IC50 = 50000.0 nM 4.30
CHEMBL3138302 IC50 = 50000.0 nM 4.30
CHEMBL3138314 IC50 = 51200.0 nM 4.29
CHEMBL3137952 IC50 = 64600.0 nM 4.19
CHEMBL3137957 IC50 > 55000.0 nM -
CHEMBL3138270 IC50 > 52000.0 nM -
CHEMBL3138393 IC50 > 52000.0 nM -
CHEMBL3137946 IC50 > 59000.0 nM -