Assay Detail
Binding
CHEMBL808739
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In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysates
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
NAD-dependent histone deacetylase SIR2 (CHEMBL3275) ↗| Type | SINGLE PROTEIN |
| Organism | Saccharomyces cerevisiae S288c |
Publication
Inhibitors of Sir2: evaluation of splitomicin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 4.34 | 5.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL316059 | 1,8-NAPHTHALIC ANHYDRIDE | — | 1 | 5.06 |
| CHEMBL313393 | — | — | 1 | 4.92 |
| CHEMBL314311 | — | — | 1 | 4.60 |
| CHEMBL91134 | — | — | 1 | 4.57 |
| CHEMBL313293 | — | — | 1 | 4.57 |
| CHEMBL88683 | — | — | 1 | 4.57 |
| CHEMBL88830 | — | — | 1 | 4.41 |
| CHEMBL327644 | — | — | 1 | 4.39 |
| CHEMBL315508 | — | — | 1 | 4.37 |
| CHEMBL90386 | — | — | 1 | 4.36 |
| CHEMBL86831 | — | — | 1 | 4.28 |
| CHEMBL314020 | — | — | 1 | 4.23 |
| CHEMBL91528 | — | — | 1 | 4.19 |
| CHEMBL88770 | — | — | 1 | 4.16 |
| CHEMBL88987 | — | — | 1 | 4.14 |
| CHEMBL86537 | SPLITOMICIN | — | 1 | 4.13 |
| CHEMBL88130 | — | — | 1 | 4.09 |
| CHEMBL424248 | — | — | 1 | 4.07 |
| CHEMBL89585 | — | — | 1 | 4.07 |
| CHEMBL89791 | — | — | 1 | 4.05 |
| CHEMBL89717 | — | — | 1 | 4.01 |
| CHEMBL87081 | — | — | 1 | - |
| CHEMBL89891 | — | — | 1 | - |
| CHEMBL6466 | COUMARIN | 4.0 | 1 | - |
| CHEMBL88194 | — | — | 1 | - |
| CHEMBL89611 | — | — | 1 | - |
| CHEMBL313262 | — | — | 1 | - |
| CHEMBL89525 | — | — | 1 | - |
| CHEMBL89698 | — | — | 1 | - |
| CHEMBL315073 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL316059 | 1,8-NAPHTHALIC ANHYDRIDE | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL313393 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL314311 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL91134 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL313293 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL88683 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL88830 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL327644 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL315508 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL90386 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL86831 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL314020 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL91528 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL88770 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL88987 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL86537 | SPLITOMICIN | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL88130 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL424248 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL89585 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL89791 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL89717 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL85078 | — | IC50 | >= | 150000.0 | nM | - |
| CHEMBL328231 | — | IC50 | = | 131000.0 | nM | - |
| CHEMBL313616 | — | IC50 | >= | 150000.0 | nM | - |
| CHEMBL88361 | — | IC50 | >= | 150000.0 | nM | - |
| CHEMBL284584 | — | IC50 | >= | 150000.0 | nM | - |
| CHEMBL89306 | DIHYDROCOUMARIN | IC50 | = | 122000.0 | nM | - |
| CHEMBL314070 | — | IC50 | = | 134000.0 | nM | - |
| CHEMBL88845 | — | IC50 | >= | 150000.0 | nM | - |
| CHEMBL313497 | — | IC50 | >= | 150000.0 | nM | - |
| CHEMBL89382 | — | IC50 | >= | 150000.0 | nM | - |
| CHEMBL89217 | — | IC50 | = | 111000.0 | nM | - |
| CHEMBL88751 | — | IC50 | = | 128000.0 | nM | - |
| CHEMBL315073 | — | IC50 | >= | 150000.0 | nM | - |
| CHEMBL89698 | — | IC50 | >= | 150000.0 | nM | - |
| CHEMBL89525 | — | IC50 | >= | 150000.0 | nM | - |
| CHEMBL313262 | — | IC50 | = | 125000.0 | nM | - |
| CHEMBL89611 | — | IC50 | = | 125000.0 | nM | - |
| CHEMBL88194 | — | IC50 | >= | 150000.0 | nM | - |
| CHEMBL6466 | COUMARIN | IC50 | >= | 150000.0 | nM | - |
| CHEMBL89891 | — | IC50 | >= | 150000.0 | nM | - |
| CHEMBL87081 | — | IC50 | >= | 150000.0 | nM | - |