Assay Detail
Functional
CHEMBL808801
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Conformational analysis of three NK1 tripeptide antagonists: a proton nuclear magnetic resonance study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.80 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL156128 | — | — | 1 | 9.30 |
| CHEMBL157858 | — | — | 1 | 9.10 |
| CHEMBL156186 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL156128 | — | Kd | = | 0.5012 | nM | 9.30 |
| CHEMBL157858 | — | Kd | = | 0.7943 | nM | 9.10 |
| CHEMBL156186 | — | Kd | = | 10.0 | nM | 8.00 |