Assay Detail
Binding
CHEMBL808805
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Competitive inhibition of Subtilisin Carlsberg enzyme from Bacillus lentus
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lederbergia lenta |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Probing the specificity of the S1 binding site of M222 mutants of subtilisin B. lentus with boronic acid inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 4.53 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20945 | — | — | 1 | 5.10 |
| CHEMBL20726 | — | — | 1 | 5.00 |
| CHEMBL21447 | — | — | 1 | 4.72 |
| CHEMBL20866 | — | — | 1 | 4.64 |
| CHEMBL20421 | — | — | 1 | 4.43 |
| CHEMBL79870 | — | — | 1 | 4.24 |
| CHEMBL20852 | — | — | 1 | 4.12 |
| CHEMBL21485 | PHENYLBORONIC ACID | — | 1 | 4.00 |
| CHEMBL21848 | — | — | 1 | - |
| CHEMBL20461 | PHENETHYLBORONIC ACID | — | 1 | - |
| CHEMBL21427 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20945 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL20726 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL21447 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL20866 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL20421 | — | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL79870 | — | Ki | = | 58000.0 | nM | 4.24 |
| CHEMBL20852 | — | Ki | = | 75000.0 | nM | 4.12 |
| CHEMBL21485 | PHENYLBORONIC ACID | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL21848 | — | Ki | = | 120000.0 | nM | - |
| CHEMBL20461 | PHENETHYLBORONIC ACID | Ki | = | 257000.0 | nM | - |
| CHEMBL21427 | — | Ki | = | 180000.0 | nM | - |