Assay Detail
Binding
CHEMBL809137
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against squalene hopene cyclase from Alicyclobacillus acidocaldarius
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Alicyclobacillus acidocaldarius |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Squalene--hopene cyclase (CHEMBL3569) ↗| Type | SINGLE PROTEIN |
| Organism | Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC27009 / DSM 446 / 104-1A) (Bacillus acidocaldarius) |
Publication
Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.90 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62855 | — | — | 1 | 7.75 |
| CHEMBL65553 | — | — | 1 | 7.64 |
| CHEMBL65230 | — | — | 1 | 7.54 |
| CHEMBL292514 | — | — | 1 | 7.42 |
| CHEMBL63524 | — | — | 1 | 7.40 |
| CHEMBL65601 | — | — | 1 | 7.31 |
| CHEMBL292084 | — | — | 1 | 7.30 |
| CHEMBL293005 | — | — | 1 | 7.23 |
| CHEMBL304858 | — | — | 1 | 7.22 |
| CHEMBL63522 | — | — | 1 | 7.21 |
| CHEMBL65296 | — | — | 1 | 7.12 |
| CHEMBL305328 | — | — | 1 | 7.12 |
| CHEMBL445353 | — | — | 1 | 7.10 |
| CHEMBL416694 | — | — | 1 | 7.02 |
| CHEMBL291640 | — | — | 1 | 6.91 |
| CHEMBL63630 | — | — | 1 | 6.89 |
| CHEMBL294809 | — | — | 1 | 6.85 |
| CHEMBL66638 | — | — | 1 | 6.76 |
| CHEMBL66202 | — | — | 1 | 6.75 |
| CHEMBL65024 | — | — | 1 | 6.73 |
| CHEMBL65730 | — | — | 1 | 6.55 |
| CHEMBL66424 | — | — | 1 | 6.54 |
| CHEMBL67133 | — | — | 1 | 6.51 |
| CHEMBL305157 | — | — | 1 | 6.48 |
| CHEMBL66412 | — | — | 1 | 6.39 |
| CHEMBL262532 | — | — | 1 | 6.12 |
| CHEMBL66359 | — | — | 1 | 5.92 |
| CHEMBL417571 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62855 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL65553 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL65230 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL292514 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL63524 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL65601 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL292084 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL293005 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL304858 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL63522 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL65296 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL305328 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL445353 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL416694 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL291640 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL63630 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL294809 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL66638 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL66202 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL65024 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL65730 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL66424 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL67133 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL305157 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL66412 | — | IC50 | = | 406.0 | nM | 6.39 |
| CHEMBL262532 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL66359 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL417571 | — | IC50 | = | 2800.0 | nM | 5.55 |