Assay Detail
Binding
CHEMBL809138
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Inhibitory activity against squalene hopene cyclase from Alicyclobacillus acidocaldarius expressed in Escherichia coli
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Alicyclobacillus acidocaldarius |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Squalene--hopene cyclase (CHEMBL3569) ↗| Type | SINGLE PROTEIN |
| Organism | Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC27009 / DSM 446 / 104-1A) (Bacillus acidocaldarius) |
Publication
Farnesyloxycoumarins, a new class of squalene-hopene cyclase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.64 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL367931 | — | — | 1 | 5.82 |
| CHEMBL427120 | — | — | 1 | 5.60 |
| CHEMBL177697 | FARNESIFEROL C | — | 1 | 5.16 |
| CHEMBL178219 | — | — | 1 | 4.19 |
| CHEMBL174435 | — | — | 1 | 4.17 |
| CHEMBL156127 | UMBELLIPRENIN | — | 1 | 4.16 |
| CHEMBL174839 | FERULENOL | — | 1 | 4.05 |
| CHEMBL178379 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL367931 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL427120 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL177697 | FARNESIFEROL C | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL178219 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL174435 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL156127 | UMBELLIPRENIN | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL174839 | FERULENOL | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL178379 | — | IC50 | = | 100000.0 | nM | 4.00 |