Assay Detail
Binding
CHEMBL809147
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Inhibitory activity against squalene synthase (SQS) obtained from HepG2 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HepG2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
J-104,123, a novel and orally-active inhibitor of squalene synthase: Stereoselective synthesis and cholesterol lowering effects in dogs
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.76 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61985 | — | — | 1 | 9.28 |
| CHEMBL143820 | — | — | 1 | 8.60 |
| CHEMBL356514 | — | — | 1 | 8.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61985 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL143820 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL356514 | — | IC50 | = | 3.9 | nM | 8.41 |