Assay Detail
Functional
CHEMBL809289
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In vitro thromboxane receptor antagonist against U-46619 induced aggregation of washed human platelets
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Oxa-prostanoid analogs. Identification of an orally effective, dual thromboxane receptor antagonist /thromboxane synthase inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.79 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65414 | — | — | 1 | 7.75 |
| CHEMBL63040 | — | — | 3 | 7.58 |
| CHEMBL302457 | — | — | 1 | 7.06 |
| CHEMBL65622 | — | — | 1 | 6.10 |
| CHEMBL294353 | — | — | 1 | 6.09 |
| CHEMBL280728 | RIDOGREL | 2.0 | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65414 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL63040 | — | IC50 | = | 26.5 | nM | 7.58 |
| CHEMBL63040 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL302457 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL63040 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL65622 | — | IC50 | = | 795.0 | nM | 6.10 |
| CHEMBL294353 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL280728 | RIDOGREL | IC50 | = | 1280.0 | nM | 5.89 |