Assay Detail
Functional
CHEMBL809291
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro for antagonistic activity against thromboxane synthase receptor
25
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 3. Synthesis and biological activities of oxazolecarboxamide-substituted omega-phenyl-omega-(3-pyridyl)alkenoic acid derivatives and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 25 | 6.69 | 7.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147444 | — | — | 1 | 7.56 |
| CHEMBL346644 | — | — | 1 | 7.36 |
| CHEMBL150252 | — | — | 1 | 7.28 |
| CHEMBL150206 | — | — | 1 | 7.24 |
| CHEMBL151519 | — | — | 2 | 7.20 |
| CHEMBL150436 | — | — | 1 | 7.19 |
| CHEMBL151083 | — | — | 1 | 7.13 |
| CHEMBL150563 | — | — | 1 | 7.08 |
| CHEMBL150660 | — | — | 1 | 7.06 |
| CHEMBL150289 | — | — | 1 | 6.95 |
| CHEMBL151091 | — | — | 1 | 6.92 |
| CHEMBL357723 | — | — | 1 | 6.92 |
| CHEMBL57576 | — | — | 1 | 6.87 |
| CHEMBL291539 | — | — | 1 | 6.82 |
| CHEMBL151860 | — | — | 1 | 6.81 |
| CHEMBL434449 | — | — | 1 | 6.78 |
| CHEMBL347343 | — | — | 1 | 6.76 |
| CHEMBL147308 | — | — | 1 | 6.32 |
| CHEMBL60710 | — | — | 1 | 6.10 |
| CHEMBL358012 | — | — | 1 | 5.85 |
| CHEMBL150598 | — | — | 1 | 5.17 |
| CHEMBL280728 | RIDOGREL | 2.0 | 1 | 5.10 |
| CHEMBL26820 | (E)-ISBOGREL | — | 1 | 5.09 |
| CHEMBL424139 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147444 | — | Kd | = | 27.3 | nM | 7.56 |
| CHEMBL346644 | — | Kd | = | 43.3 | nM | 7.36 |
| CHEMBL150252 | — | Kd | = | 52.2 | nM | 7.28 |
| CHEMBL150206 | — | Kd | = | 58.2 | nM | 7.24 |
| CHEMBL151519 | — | Kd | = | 62.6 | nM | 7.20 |
| CHEMBL150436 | — | Kd | = | 64.3 | nM | 7.19 |
| CHEMBL151083 | — | Kd | = | 74.3 | nM | 7.13 |
| CHEMBL150563 | — | Kd | = | 82.4 | nM | 7.08 |
| CHEMBL150660 | — | Kd | = | 86.7 | nM | 7.06 |
| CHEMBL151519 | — | Kd | = | 104.7 | nM | 6.98 |
| CHEMBL150289 | — | Kd | = | 113.3 | nM | 6.95 |
| CHEMBL357723 | — | Kd | = | 121.7 | nM | 6.92 |
| CHEMBL151091 | — | Kd | = | 119.3 | nM | 6.92 |
| CHEMBL57576 | — | Kd | = | 135.2 | nM | 6.87 |
| CHEMBL291539 | — | Kd | = | 153.1 | nM | 6.82 |
| CHEMBL151860 | — | Kd | = | 155.8 | nM | 6.81 |
| CHEMBL434449 | — | Kd | = | 165.4 | nM | 6.78 |
| CHEMBL347343 | — | Kd | = | 173.3 | nM | 6.76 |
| CHEMBL147308 | — | Kd | = | 483.0 | nM | 6.32 |
| CHEMBL60710 | — | Kd | = | 791.2 | nM | 6.10 |
| CHEMBL358012 | — | Kd | = | 1404.9 | nM | 5.85 |
| CHEMBL150598 | — | Kd | = | 6724.2 | nM | 5.17 |
| CHEMBL280728 | RIDOGREL | Kd | = | 8000.0 | nM | 5.10 |
| CHEMBL26820 | (E)-ISBOGREL | Kd | = | 8200.0 | nM | 5.09 |
| CHEMBL424139 | — | Kd | > | 10000.0 | nM | - |