Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL809308

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibitory activity against uninfected T4 cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type MT4
Confidence 1 — Organism
Curated By Expert

Target

MT4 (CHEMBL388)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of certain alpha,beta-unsaturated ketones and their corresponding fused pyridines as antiviral and cytotoxic agents.
El-Subbagh HI, Abu-Zaid SM, Mahran MA, Badria FA, Al-Obaid AM.
J Med Chem (2000) 43 : 2915 -2921
PubMed 10956199 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.78 5.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL98764 1 5.17
CHEMBL319097 1 5.05
CHEMBL316846 1 5.04
CHEMBL319317 1 4.96
CHEMBL98369 1 4.82
CHEMBL316931 1 4.56
CHEMBL316596 1 4.52
CHEMBL317089 1 4.47
CHEMBL129 ZIDOVUDINE 4.0 1 4.45
CHEMBL316744 1 -
CHEMBL100105 1 -
CHEMBL330609 1 -
CHEMBL318719 1 -
CHEMBL95379 1 -
CHEMBL317804 1 -
CHEMBL98841 1 -
CHEMBL100326 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL98764 IC50 = 6800.0 nM 5.17
CHEMBL319097 IC50 = 9000.0 nM 5.05
CHEMBL316846 IC50 = 9100.0 nM 5.04
CHEMBL319317 IC50 = 11100.0 nM 4.96
CHEMBL98369 IC50 = 15200.0 nM 4.82
CHEMBL316931 IC50 = 27600.0 nM 4.56
CHEMBL316596 IC50 = 30400.0 nM 4.52
CHEMBL317089 IC50 = 34000.0 nM 4.47
CHEMBL129 ZIDOVUDINE IC50 = 35600.0 nM 4.45
CHEMBL316744 IC50 = 126000.0 nM -
CHEMBL100105 IC50 > 200000.0 nM -
CHEMBL330609 IC50 > 200000.0 nM -
CHEMBL318719 IC50 > 200000.0 nM -
CHEMBL95379 IC50 > 200000.0 nM -
CHEMBL317804 IC50 = 104000.0 nM -
CHEMBL98841 IC50 > 200000.0 nM -
CHEMBL100326 IC50 > 200000.0 nM -