Assay Detail
Binding
CHEMBL809315
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Inhibition of TIE-2 kinase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.20 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47203 | — | — | 1 | 6.60 |
| CHEMBL48554 | — | — | 1 | 5.29 |
| CHEMBL296534 | — | — | 1 | 5.18 |
| CHEMBL296103 | — | — | 1 | 4.93 |
| CHEMBL431342 | — | — | 1 | 4.92 |
| CHEMBL297359 | — | — | 1 | 4.78 |
| CHEMBL47202 | — | — | 1 | 4.67 |
| CHEMBL416444 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47203 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL48554 | — | IC50 | = | 5150.0 | nM | 5.29 |
| CHEMBL296534 | — | IC50 | = | 6620.0 | nM | 5.18 |
| CHEMBL296103 | — | IC50 | = | 11620.0 | nM | 4.93 |
| CHEMBL431342 | — | IC50 | = | 12160.0 | nM | 4.92 |
| CHEMBL297359 | — | IC50 | = | 16710.0 | nM | 4.78 |
| CHEMBL47202 | — | IC50 | = | 21380.0 | nM | 4.67 |
| CHEMBL416444 | — | IC50 | > | 50000.0 | nM | - |