Assay Detail

CHEMBL809326

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Effective concentration to inhibit HIV replication in TK CEM-SS cell line

ChEMBL ↗

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Target

CEM-SS (CHEMBL614548) ↗

Open DB target context

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Primary target CEM-SS

CHEMBL614548

Anchored from Assay target.

Protein identity CEM-SS

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	CEM-SS
Confidence	1 — Organism
Curated By	Intermediate

Target

CEM-SS (CHEMBL614548) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Rational design of a new series of pronucleotide.

Beltran T, Egron D, Pompon A, Lefebvre I, Périgaud C, Gosselin G, Aubertin A, Imbach J.
Bioorg Med Chem Lett (2001) 11 : 1775 -1777
PubMed 11425558 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	6.20	6.20

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL298640	—	—	1	6.20
CHEMBL129	ZIDOVUDINE	4.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL298640	—	EC50	=	630.0	nM	6.20
CHEMBL129	ZIDOVUDINE	EC50	>	100000.0	nM	-