Assay Detail
Binding
CHEMBL809536
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit enzymatic cleavage of the chromogenic substrate (H-D-Phe-Pip-Arg-pNA) thrombin in vitro.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New orally active serine protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.80 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85136 | — | — | 1 | 5.44 |
| CHEMBL85164 | CAMOSTAT MESILATE | 3.0 | 1 | 4.50 |
| CHEMBL85154 | — | — | 1 | 4.46 |
| CHEMBL433135 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85136 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL85164 | CAMOSTAT MESILATE | IC50 | = | 31600.0 | nM | 4.50 |
| CHEMBL85154 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL433135 | — | IC50 | = | 107500.0 | nM | - |