Assay Detail
Functional
CHEMBL809537
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antagonist activity against Thrombin induced gel-filtered platelet (GFP) aggregation at 0.15 nM.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery and optimization of a novel series of thrombin receptor (par-1) antagonists: potent, selective peptide mimetics based on indole and indazole templates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.68 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275003 | — | — | 1 | 6.47 |
| CHEMBL7642 | RWJ-58259 | — | 1 | 6.43 |
| CHEMBL428311 | — | — | 1 | 6.24 |
| CHEMBL7610 | RWJ-54003 | — | 1 | 6.05 |
| CHEMBL267059 | — | — | 1 | 5.97 |
| CHEMBL269345 | — | — | 1 | 5.63 |
| CHEMBL275946 | — | — | 1 | 4.88 |
| CHEMBL7627 | — | — | 1 | 4.75 |
| CHEMBL268328 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275003 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL7642 | RWJ-58259 | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL428311 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL7610 | RWJ-54003 | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL267059 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL269345 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL275946 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL7627 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL268328 | — | IC50 | = | 18200.0 | nM | 4.74 |