Assay Detail
Binding
CHEMBL809577
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In vitro inhibitory concentration against src-tyrosine kinase
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.20 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL170984 | — | — | 1 | 8.30 |
| CHEMBL354145 | — | — | 1 | 8.00 |
| CHEMBL169643 | — | — | 1 | 8.00 |
| CHEMBL422564 | — | — | 1 | 8.00 |
| CHEMBL172450 | — | — | 1 | 8.00 |
| CHEMBL352977 | — | — | 1 | 8.00 |
| CHEMBL171125 | — | — | 1 | 7.85 |
| CHEMBL171558 | — | — | 1 | 7.80 |
| CHEMBL353070 | — | — | 1 | 7.70 |
| CHEMBL167890 | — | — | 1 | 7.55 |
| CHEMBL171745 | — | — | 1 | 7.52 |
| CHEMBL169797 | — | — | 1 | 7.43 |
| CHEMBL355282 | — | — | 1 | 7.40 |
| CHEMBL352877 | — | — | 1 | 7.30 |
| CHEMBL171003 | — | — | 1 | 6.75 |
| CHEMBL169473 | — | — | 1 | 6.60 |
| CHEMBL169231 | — | — | 1 | 6.58 |
| CHEMBL168885 | — | — | 1 | 6.57 |
| CHEMBL171423 | — | — | 1 | 6.43 |
| CHEMBL171373 | — | — | 1 | 6.36 |
| CHEMBL353901 | — | — | 1 | 6.32 |
| CHEMBL171368 | — | — | 1 | 6.25 |
| CHEMBL169725 | — | — | 1 | 6.12 |
| CHEMBL355102 | — | — | 1 | 6.02 |
| CHEMBL169186 | — | — | 1 | - |
| CHEMBL172518 | — | — | 1 | - |
| CHEMBL173799 | — | — | 1 | - |
| CHEMBL369360 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL170984 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL354145 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL169643 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL422564 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL172450 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL352977 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL171125 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL171558 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL353070 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL167890 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL171745 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL169797 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL355282 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL352877 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL171003 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL169473 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL169231 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL168885 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL171423 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL171373 | — | IC50 | = | 433.0 | nM | 6.36 |
| CHEMBL353901 | — | IC50 | = | 477.0 | nM | 6.32 |
| CHEMBL171368 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL169725 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL355102 | — | IC50 | = | 963.0 | nM | 6.02 |
| CHEMBL169186 | — | IC50 | < | 4.0 | nM | - |
| CHEMBL172518 | — | IC50 | < | 4.0 | nM | - |
| CHEMBL173799 | — | IC50 | < | 4.0 | nM | - |
| CHEMBL369360 | — | IC50 | < | 4.0 | nM | - |