Compound Detail
CHEMBL169473
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Basic Information
| ChEMBL ID | CHEMBL169473 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FMZCWRYXPHDICO-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
311.3
MW (Da)
3.40
ALogP
6
HBA
1
HBD
65.5
PSA (Ų)
0.78
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src CHEMBL267 | IC50 | 6.6 | 6.6 | 253.0 | 1 |
| Proto-oncogene tyrosine-protein kinase receptor Ret CHEMBL2041 | IC50 | 5.92 | 5.92 | 1200.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 5.32 | 5.32 | 4800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src | IC50 | = | 253.0 | nM | 6.6 | In vitro inhibitory concentration against src-tyrosine kinase | 14761189 |
| Proto-oncogene tyrosine-protein kinase receptor Ret | IC50 | = | 1200.0 | nM | 5.92 | Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in b... | 26874741 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 4800.0 | nM | 5.32 | Inhibition of recombinant His-tagged human KDR expressed in insect Sf21 cells pr... | 26874741 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14761189 | 10.1021/jm030317k | Proto-oncogene tyrosine-protein kinase Src | 1 |
| - | 10.6019/CHEMBL3301361 | No relevant target | 1 |
| 26874741 | 10.1016/j.ejmech.2016.01.039 | Vascular endothelial growth factor receptor 2 | 1 |
| 26874741 | 10.1016/j.ejmech.2016.01.039 | Proto-oncogene tyrosine-protein kinase receptor Ret | 1 |
| 26874741 | 10.1016/j.ejmech.2016.01.039 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine