Assay Detail
Binding
CHEMBL809674
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against thromboxane B2 formation (TXA2 synthase) by incubating prostaglandin H2 (PGH-2) with horse platelet microsomes
74
Total Activities
73
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Thromboxane synthetase inhibitors (TXSI). Design, synthesis, and evaluation of a novel series of omega-pyridylalkenoic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 74 | 7.12 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98477 | — | — | 1 | 7.75 |
| CHEMBL320009 | — | — | 1 | 7.72 |
| CHEMBL98715 | — | — | 1 | 7.70 |
| CHEMBL432014 | — | — | 1 | 7.68 |
| CHEMBL26820 | (E)-ISBOGREL | — | 1 | 7.58 |
| CHEMBL98952 | — | — | 1 | 7.55 |
| CHEMBL101841 | — | — | 1 | 7.55 |
| CHEMBL319769 | — | — | 1 | 7.54 |
| CHEMBL430495 | — | — | 1 | 7.54 |
| CHEMBL101542 | — | — | 1 | 7.52 |
| CHEMBL98443 | — | — | 1 | 7.52 |
| CHEMBL98840 | — | — | 1 | 7.52 |
| CHEMBL98439 | — | — | 1 | 7.51 |
| CHEMBL98444 | — | — | 1 | 7.50 |
| CHEMBL101813 | — | — | 1 | 7.50 |
| CHEMBL329064 | — | — | 1 | 7.48 |
| CHEMBL320158 | — | — | 1 | 7.47 |
| CHEMBL28196 | ISBOGREL | 2.0 | 2 | 7.44 |
| CHEMBL330592 | — | — | 1 | 7.43 |
| CHEMBL328646 | — | — | 1 | 7.42 |
| CHEMBL329965 | — | — | 1 | 7.39 |
| CHEMBL97978 | — | — | 1 | 7.39 |
| CHEMBL430678 | — | — | 1 | 7.39 |
| CHEMBL98601 | — | — | 1 | 7.38 |
| CHEMBL98901 | — | — | 1 | 7.38 |
| CHEMBL419900 | — | — | 1 | 7.37 |
| CHEMBL95554 | — | — | 1 | 7.35 |
| CHEMBL97891 | — | — | 1 | 7.32 |
| CHEMBL263019 | — | — | 1 | 7.30 |
| CHEMBL330442 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98477 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL320009 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL98715 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL432014 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL26820 | (E)-ISBOGREL | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL98952 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL101841 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL319769 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL430495 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL98840 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL98443 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL101542 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL98439 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL98444 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL101813 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL329064 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL320158 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL28196 | ISBOGREL | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL330592 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL328646 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL329965 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL430678 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL97978 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL98601 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL98901 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL419900 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL95554 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL97891 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL330442 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL263019 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL28196 | ISBOGREL | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL99223 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL98282 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL330187 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL101812 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL98690 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL420086 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL98845 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL264871 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL328191 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL99319 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL318048 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL102200 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL101098 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL316848 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL98941 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL330440 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL99551 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL101785 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL100755 | — | IC50 | = | 82.0 | nM | 7.09 |