Assay Detail
Binding
CHEMBL809679
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Tested in vitro against TXA2 synthetase inhibitory activity in human microsome
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 2. 4-(3-Pyridyl)-1(2H)-phthalazinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.14 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11662 | OZAGREL | 4.0 | 1 | 7.22 |
| CHEMBL335687 | — | — | 1 | 5.80 |
| CHEMBL130453 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11662 | OZAGREL | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL335687 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL130453 | — | IC50 | = | 3900.0 | nM | 5.41 |