Assay Detail
Functional
CHEMBL809692
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Immunosuppressive activity examined in an in vitro model of allogenic T-lymphocyte activation (by MLR assay)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Retention of immunosuppressant activity in an ascomycin analogue lacking a hydrogen-bonding interaction with FKBP12.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.68 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71458 | — | — | 1 | 9.82 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 9.64 |
| CHEMBL8597 | ASCOMYCIN | — | 1 | 9.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71458 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL8597 | ASCOMYCIN | IC50 | = | 0.26 | nM | 9.59 |