Assay Detail

CHEMBL809733

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Functional

Cell free inhibiting activity against Streptococcus pneumoniae 5635(Wild type ribosomes for transcription/translation assay)

ChEMBL ↗

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Target

Streptococcus pneumoniae (CHEMBL347) ↗

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Primary target Streptococcus pneumoniae

CHEMBL347

Anchored from Assay target.

Protein identity Streptococcus pneumoniae

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Streptococcus pneumoniae
Confidence	1 — Organism
Curated By	Intermediate

Target

Streptococcus pneumoniae (CHEMBL347) ↗

Type	ORGANISM
Organism	Streptococcus pneumoniae

Publication

Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.

Ma Z, Clark RF, Brazzale A, Wang S, Rupp MJ, Li L, Griesgraber G, Zhang S, Yong H, Phan LT, Nemoto PA, Chu DT, Plattner JJ, Zhang X, Zhong P, Cao Z, Nilius AM, Shortridge VD, Flamm R, Mitten M, Meulbroek J, Ewing P, Alder J, Or YS.
J Med Chem (2001) 44 : 4137 -4156
PubMed 11708916 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.91	7.05

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1741	CLARITHROMYCIN	4.0	1	7.05
CHEMBL529	AZITHROMYCIN	4.0	1	6.77

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1741	CLARITHROMYCIN	IC50	=	90.0	nM	7.05
CHEMBL529	AZITHROMYCIN	IC50	=	170.0	nM	6.77