Assay Detail
Functional
CHEMBL809734
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Cell free inhibiting activity against erythromycin-susceptible strain Streptococcus pneumoniae 1813 (Wild type ribosomes for transcription/translation assay)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Streptococcus pneumoniae |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.17 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3989904 | CETHROMYCIN | 3.0 | 1 | 7.40 |
| CHEMBL435997 | — | — | 1 | 7.10 |
| CHEMBL334627 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3989904 | CETHROMYCIN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL435997 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL334627 | — | IC50 | = | 100.0 | nM | 7.00 |