Assay Detail
Functional
CHEMBL809735
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Cell free inhibiting activity against erythromycin-susceptible strain Streptococcus pneumoniae 1813 (methylated ribosomes for transcription/translation assay)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Streptococcus pneumoniae |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.52 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334627 | — | — | 1 | 4.60 |
| CHEMBL3989904 | CETHROMYCIN | 3.0 | 1 | 4.55 |
| CHEMBL435997 | — | — | 1 | 4.40 |
| CHEMBL335552 | — | — | 1 | - |
| CHEMBL132146 | — | — | 1 | - |
| CHEMBL335696 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334627 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3989904 | CETHROMYCIN | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL435997 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL335552 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL132146 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL335696 | — | IC50 | > | 500000.0 | nM | - |