Assay Detail
Functional
CHEMBL809979
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In vitro cytotoxicity against mouse TLX5 lymphoma cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | lymphoma |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor imidazotetrazines. 41. Conjugation of the antitumor agents mitozolomide and temozolomide to peptides and lexitropsins bearing DNA major and minor groove-binding structural motifs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.13 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL154982 | — | — | 1 | 5.82 |
| CHEMBL287431 | — | — | 1 | 5.70 |
| CHEMBL435951 | MITOZOLOMIDE | 2.0 | 1 | 5.60 |
| CHEMBL355947 | — | — | 1 | 5.43 |
| CHEMBL153358 | — | — | 1 | 5.30 |
| CHEMBL810 | TEMOZOLOMIDE | 4.0 | 1 | 5.30 |
| CHEMBL150441 | — | — | 1 | 5.16 |
| CHEMBL31897 | — | — | 1 | 4.80 |
| CHEMBL405733 | — | — | 1 | 4.60 |
| CHEMBL153071 | — | — | 1 | 4.47 |
| CHEMBL345274 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL154982 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL287431 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL435951 | MITOZOLOMIDE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL355947 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL153358 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL810 | TEMOZOLOMIDE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL150441 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL31897 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL405733 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL153071 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL345274 | — | IC50 | = | 50000.0 | nM | 4.30 |